Treating Hyperglycemia From Eryngium caeruleum M. Bieb: In-vitro α-Glucosidase, Antioxidant, in-vivo Antidiabetic and Molecular Docking-Based Approaches
نویسندگان
چکیده
منابع مشابه
Synthesis, In Vitro α-Glucosidase Inhibitory Activity and Molecular Docking Studies of Novel Benzothiazole-Triazole Derivatives.
Benzothiazole-triazole derivatives 6a-6s have been synthesized and characterized by ¹HNMR and 13C-NMR. All synthetic compounds were screened for their in vitro α-glucosidase inhibitory activity by using Baker's yeast α-glucosidase enzyme. The majority of compounds exhibited a varying degree of α-glucosidase inhibitory activity with IC50 values between 20.7 and 61.1 μM when compared with standar...
متن کاملتأثیر کاربرد کودهای آلی بر عملکرد و اجزای عملکرد زولنگ (Eryngium caeruleum M. Bieb.) تحت تأثیر همزیستی میکوریزایی
زولنگ (Eryngium caeruleum M. Bieb.) یکی از مهمترین گونه‌های جنس بوقناق در شمال ایران است که از آن به‌عنوان سبزی صحرایی استفاده می‌شود. به‌منظور بررسی اثر کودهای آلی و همزیستی میکوریزایی بر اجزای عملکرد و درصد اسانس زولنگ آزمایشی به‌صورت فاکتوریل در قالب طرح کامل تصادفی با 8 تیمار و 4 تکرار در سال 1393 در ساری اجرا شد. فاکتورهای آزمایش شامل میکوریزا گونه Glomus mosseae در دو سطح (صفر و 200 اسپور...
متن کاملIsolation, in vitro antidiabetic, antioxidant activity and molecular docking studies of pentacyclic triterpenoids from Syzygium alternifolium (wt.) Walp bark
Diabetes mellitus type 2 is a metabolic disorder characterized by hyperglycemia including insulin resistance and relative lack of insulin. Type 2 diabetes is expected to reduce ten-year-shorter life expectancy. In this research article, we have isolated two terpenoids from the stem bark of Syzygium alternifoliumby column chromatography.The isolated compounds were identified as friedelin and 3β-...
متن کاملTarget guided isolation, in-vitro antidiabetic, antioxidant activity and molecular docking studies of some flavonoids from Albizzia Lebbeck Benth. bark
BACKGROUND Albizzia Lebbeck Benth. is traditionally important plant and is reported to possess a variety of pharmacological actions. The present research exertion was undertaken to isolate and characterized the flavonoids from the extract of stem bark of Albizzia Lebbeck Benth. and to evaluate the efficacy of the isolated flavonoids on in-vitro models of type-II diabetes. Furthermore, the resul...
متن کاملSelected Tea and Tea Pomace Extracts Inhibit Intestinal α-Glucosidase Activity in Vitro and Postprandial Hyperglycemia in Vivo
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by postprandial hyperglycemia, which is an early defect of T2DM and thus a primary target for anti-diabetic drugs. A therapeutic approach is to inhibit intestinal α-glucosidase, the key enzyme for dietary carbohydrate digestion, resulting in delayed rate of glucose absorption. Although tea extracts have been reported to have ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Chemistry
سال: 2020
ISSN: 2296-2646
DOI: 10.3389/fchem.2020.558641